UP ANSES - Dozulé Laboratory for Equine Diseases

The Dozulé laboratory for equine diseases concentrates on controlling health risks related to infectious or parasitic diseases in horses through two key focuses: (i) epidemiology and epidemiological surveillance of these diseases; (ii) improving diagnostic and test tools. Its 30-strong staff works in three research units:

• Bacteriology and Parasitology Unit

  • Molecular characterization and typing of isolates of Taylorella equigenitalis, agent of contagious equine metritis, and Taylorella asinigenitalis circulating in equine and anise populations in France and Europe.
  • Study of the ecology of the contagious equine metritis agent within the microflora of the equine genital tract with the objective of improving detection and control methods.
  • Participation in studies on virulence and antibiotic resistance in equine pathogenic bacteria from autopsy strain libraries and/or epidemiological investigations.
  • Improvement of serological and molecular diagnostic methods for dourine.
  • Evaluation of the possibility of effectively treating dourine.

• Epidemiology and Pathological Anatomy Unit

  • Epidemiology of equine mortality (qualitative and quantitative aspects).
  • Evaluation of the sensitivity of epidemiosurveillance devices for 3 equine diseases (IEA, AVE, MCE) and proposal for improvement by interconnection between the devices.
  • Study of the evolution of antibiotic resistance of the main bacterial species responsible for abortion and stillbirth in French mare.

• Virology Unit

  • Molecular characterization of equine infectious anaemia strains encountered in France and Europe.
  • Improvement of serological and molecular diagnostic methods for equine infectious anaemia.
  • Study of the role of testosterone on the persistence and replication of Equine Viral Arteritis virus (EVV).
  • Characterization of the antiviral properties of synthetic molecules on Equine Infectious Anemia Virus (EIA) and Equine Viral Arteritis Virus (EVA).